Wolves goalkeeper Dorus de Vries is poised to make his first Premier League start for the club in place of the injured Wayne Hennessey.
On-loan defender Sebastien Bassong is available after serving a one-game ban, while winger Matt Jarvis could be restored to the side.
Manchester City are still without forward Mario Balotelli, who completes a three-match ban.
Manager Roberto Mancini has reported no other injury concerns.
On paper this must go down as one of the mismatches of the season.
Manchester City are close to their best again, whacking 10 goals past West Brom and Norwich in the space of a few days, whilst Wolves are in a horrible spiral which is only taking them one way.
Relegation could be confirmed this weekend, but there will be no lasting stay of execution. So much has been written about the wisdom or otherwise of sacking Mick McCarthy, and particularly the messy process of finding a replacement, so I won't add to it other than to point out that Wolves had hardly spent a day in the bottom three this season prior to McCarthy's dismissal.
It may surprise some younger readers, but Wolves' record against Manchester City is actually rather good. They have won six of their last nine home league games against City stretching over the course of 30 years. The most recent was last season and nine of the 11 City players who started the 2 -1 defeat at Molineux then could very well be on show again; only Adebayor and Boateng are not around this time.
By the time City kick off, they will know how Manchester United have done against Everton. No matter what Roberto Mancini says in public, he will be hoping that Everton can take something from Old Trafford. If Everton do avoid defeat, then a City win over Wolves would put then in a position to go top if they win their next game - the Manchester derby.
For City there are twists and turns ahead - not so for Wolves.
Wolves won their last home meeting against Manchester City, with David Edwards scoring the decisive goal in a 2-1 victory 18 months ago.
They lead the overall head-to-head by 46 wins to 44, with 24 draws.
Wolves ended a run of seven consecutive league defeats by earning a point at Sunderland last weekend.
That goalless draw was their first clean sheet in 31 games since 27 August.
The Black Country side have the worst home record in the top flight, with three wins and 11 points from 17 matches.
They have lost a club record eight successive matches at Molineux and are winless in 10 since beating Sunderland on 4 December.
Terry Connor has taken two points from his first nine Premier League games in charge - the only manager ever to fare worse in the Premier League is his mentor Mick McCarthy (no points with Sunderland in 2003).
Steven Fletcher has failed to score in his last eight Premier League matches, equalling his longest spell without a goal.
Manager Roberto Mancini's first ever Premier League away match in charge of Manchester City was a 3-0 win at Molineux in December 2009.
They have only earned 12 points from their last 11 away matches (W3, D3, L5).
Roberto Mancini's side have the best goal difference after 34 games in Premier League history (+58). They have the best goalscoring and defensive records in the division this season.
Sergio Aguero has scored 21 league goals in 30 appearances this season. His goals at Norwich last weekend were his first outside of London or Manchester in the Premier League.
Our relegation could be confirmed over the weekend, and deservedly so. Sunderland away last week was a big improvement, but too little too late. Away win and 1-4 in City's favour.